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KMID : 0620920210530050772
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Experimental & Molecular Medicine
2021 Volume.53 No. 5 p.772 ~ p.787
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Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis
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Fang Jian
Wang Hui
Zhou Yuping
Zhang Hui
Zhou Huiting
Zhang Xiaohong
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Abstract
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Ulcerative colitis (UC) is a chronic recurrent intestinal inflammatory disease characterized by high incidence and young onset age. Recently, there have been some interesting findings in the pathogenesis of UC. The mucus barrier, which is composed of a mucin complex rich in O-glycosylation, not only provides nutrients and habitat for intestinal microbes but also orchestrates the taming of germs. In turn, the gut microbiota modulates the production and secretion of mucins and stratification of the mucus layers. Active bidirectional communication between the microbiota and its ‘slimy’ partner, the mucus barrier, seems to be a continually performed concerto, maintaining homeostasis of the gut ecological microenvironment. Any abnormalities may induce a disorder in the gut community, thereby causing inflammatory damage. Our review mainly focuses on the complicated communication between the mucus barrier and gut microbiome to explore a promising new avenue for UC therapy.
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KEYWORD
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Glycobiology, Ulcerative colitis
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